Mechanism of medicine action:
Isotretinoin works by decreasing sebaceous gland activity, leading to reduced sebum production. Additionally, it promotes the normal shedding of skin cells, preventing the clogging of hair follicles. Isotretinoin also possesses anti-inflammatory properties and alters the growth and differentiation of epithelial cells, leading to clearer skin.
Indications:
Iso-Accutane is primarily indicated for the treatment of severe, recalcitrant nodular acne in patients who are candidates for systemic therapy. It may also be used for other skin conditions as determined by a healthcare provider, depending on clinical judgment.
Contraindications:
Isotretinoin is contraindicated in pregnant women or those who may become pregnant due to its known teratogenic effects, which can cause severe fetal abnormalities. It should not be used in patients with hypersensitivity to isotretinoin, vitamin A toxicity, or certain hepatic disorders.
Precautions:
Patients must be monitored closely while on isotretinoin therapy. It is crucial to ensure that women of childbearing potential adhere to strict contraceptive measures and undergo regular pregnancy testing due to the risk of severe birth defects. Liver function tests and lipid levels should also be monitored before and during treatment.
Drug interactions:
Isotretinoin can interact with various medications. Notably, it should not be used concurrently with tetracycline antibiotics due to the increased risk of intracranial hypertension. Additionally, its absorption may be affected by certain medications that alter gastrointestinal function, and caution should be applied when combined with other teratogenic drugs or medications that affect liver enzyme activity.
Dosage:
The typical initial dose of isotretinoin for adults is about 20-40 mg/day, which may be adjusted based on clinical response and tolerance. The total course usually ranges from 4 to 6 months, with doses potentially being increased during treatment. Dosages in pediatric populations should be carefully calculated based on weight.
Storage:
Store in a dark, dry place, at room temperature. Keep out of reach of children.
Regulatory Compliance Statements:
- This product complies with relevant regulatory guidelines.
- Certified under Good Manufacturing Practices (GMP).
Safety Information:
- Overdose Instructions: In case of overdose, seek immediate medical attention.
- Adverse Reactions: Report any adverse reactions to your healthcare provider.
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